Characterization of Rat Testicular Peritubular Myoid Cells in Culture: α-Smooth Muscle Isoactin is a Specific Differentiation Marker1
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چکیده
منابع مشابه
Peritubular myoid cells have a role in postnatal testicular growth
FSH stimulates testicular growth by increasing Sertoli cell proliferation and elongation of seminiferous cords. Little is known about the peritubular myoid cells in testicular development. In order to investigate the role of peritubular myoid cells in early testicular growth in rodents, two traditional models to induce testicular growth were used: FSH treatment and hemicastration. In order to a...
متن کاملErythropoietin expression in primary rat Sertoli and peritubular myoid cells.
Kidney and liver are the major organs of erythropoietin (Epo) synthesis. However, Epo messenger RNA (mRNA) has been detected in several organs, such as brain, lung, and testis. Furthermore, functional Epo receptors have been demonstrated on different cell types, including rat Leydig cells. The aim of the study was to identify testicular cells expressing Epo mRNA and to quantitate its levels by ...
متن کاملAndrogen action via testicular peritubular myoid cells is essential for male fertility
Androgens are essential for normal spermatogenesis and male fertility, but how androgens exert this effect remains uncertain. Androgen receptors (ARs) are expressed in several testicular cell types, but continuing uncertainty exists over which cell type mediates androgen control of spermatogenesis. Androgen signaling via Sertoli cells (SCs) is essential for complete spermatogenesis, but the rol...
متن کاملExpression of smooth muscle-specific alpha-isoactin in cultured vascular smooth muscle cells: relationship between growth and cytodifferentiation
The relationship between growth and cytodifferentiation was studied in cultured rat aortic smooth muscle cells (SMCs) using expression of the smooth muscle (SM)-specific isoactins (Vanderkerckhove, J., and K. Weber, 1979, Differentiation, 14:123-133) as a marker for differentiation in these cells. Isoactin expression was evaluated by: (a) measurements of fractional isoactin content and synthesi...
متن کاملAndrogen receptor signalling in peritubular myoid cells is essential for normal differentiation and function of adult Leydig cells.
Testosterone synthesis depends on normal Leydig cell (LC) development, but the mechanisms controlling this development remain unclear. We recently demonstrated that androgen receptor (AR) ablation from a proportion of testicular peritubular myoid cells (PTM-ARKO) did not affect LC number, but resulted in compensated LC failure. The current study extends these investigations, demonstrating that ...
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ژورنال
عنوان ژورنال: Biology of Reproduction
سال: 1989
ISSN: 0006-3363,1529-7268
DOI: 10.1095/biolreprod42.2.351